Bcs Class 2 Drug
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This is the list of Schedule II drugs as defined by the United StatesControlled Substances Act.[1]The following findings are required for drugs to be placed in this schedule:[2]
- The drug or other substance has a high potential for abuse.
- The drug or other substance has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions.
- Abuse of the drug or other substances may lead to severe psychological or physical dependence.
The complete list of Schedule II drugs follows.[1] The Administrative Controlled Substances Code Number for each drug is included.
BCS CLASS BOUNDARIES Class boundary parameters (i.e., solubility, permeability, and dissolution) are for easy identification and determination of BCS class (2, 4 11). Solubility: A drug substance is considered highly soluble when the highest dose strength is soluble in 250 mL or less of water over a pH range of 1–7.5 at 37 °C (4, 11, 12, 13). SYSTEM DESIGN AND IMPLEMENTATION Our hybrid expert system is designed to generate and validate drug-formulation designs for BCS class II. Pi-roxicam, a class II drug is used as a sample drug in this paper. For a recommended formulation, the current proto-type only validates the dissolution rate, which is one of the most crucial drug delivery.
| ACSCN | Class | Drug |
|---|---|---|
| 9050 | opiate | Codeine |
| 9334 | opiate | Dihydroetorphine |
| 9190 | opiate | Ethylmorphine |
| 9059 | opiate | Etorphine hydrochloride |
| 9640 | opiate | Granulated opium |
| 9193 | opiate | Hydrocodone |
| 9150 | opiate | Hydromorphone |
| 9260 | opiate | Metopon |
| 9300 | opiate | Morphine |
| 9610 | opiate | Opium extracts |
| 9620 | opiate | Opium fluid |
| 9330 | opiate | Oripavine |
| 9143 | opiate | Oxycodone |
| 9652 | opiate | Oxymorphone |
| 9639 | opiate | Powdered opium |
| 9600 | opiate | Raw opium |
| 9333 | opiate | Thebaine |
| 9630 | opiate | Tincture of opium |
| opiate | Opium poppy and poppy straw | |
| 9040 | stimulant | Coca, leaves and any salt, compound, derivative or preparation of coca leaves |
| 9041 | stimulant | Cocaine, and its salts, isomers, derivatives and salts of isomers and derivatives |
| 9180 | stimulant | Ecgonine, and its salts, isomers, derivatives and salts of isomers and derivatives |
| 9670 | opiate | Concentrate of poppy straw (the crude extract of poppy straw in either liquid, solid or powder form which contains the phenanthrene alkaloids of the opium poppy) |
| 9737 | opioid | Alfentanil |
| 9010 | opiate | Alphaprodine |
| 9020 | opioid | Anileridine |
| 9800 | opiate | Bezitramide |
| 9273 | opioid | Bulk dextropropoxyphene (non-dosage forms) |
| 9743 | opioid | Carfentanil |
| 9120 | opiate | Dihydrocodeine |
| 9170 | opioid | Diphenoxylate |
| 9801 | opioid | Fentanyl |
| 9226 | opioid | Isomethadone |
| 9648 | opiate | Levo-alphacetylmethadol |
| 9210 | opiate | Levomethorphan |
| 9220 | opiate | Levorphanol |
| 9240 | opioid | Metazocine |
| 9250 | opioid | Methadone |
| 9254 | opiate intermediate | Methadone intermediate: 4-cyano-2-dimethylamino-4,4-diphenyl butane |
| 9802 | opiate intermediate | Moramide intermediate: 2-methyl-3-morpholino-1,1-diphenylpropane-carboxylic acid |
| 9230 | opioid | Pethidine (meperidine) |
| 9232 | opiate intermediate | Pethidine intermediate A: 4-cyano-1-methyl-4-phenylpiperidine |
| 9233 | opiate intermediate | Pethidine intermediate B, ethyl-4-phenylpiperidine-4-carboxylate |
| 9234 | opiate intermediate | Pethidine intermediate C, 1-methyl-4-phenylpiperidine-4-carboxylic acid |
| 9715 | opiate | Phenazocine |
| 9730 | opiate | Piminodine |
| 9732 | opiate | Racemethorphan |
| 9733 | opiate | Racemorphan |
| 9739 | opiate | Remifentanil |
| 9740 | opiate | Sufentanil |
| 9780 | opiate | Tapentadol |
| 1100 | stimulant | Amphetamine, its salts, optical isomers, and salts of its optical isomers (Adderall) |
| 1105 | stimulant | Methamphetamine, its salts, isomers, and salts of its isomers |
| 1631 | stimulant | Phenmetrazine and its salts |
| 1724 | stimulant | Methylphenidate (Ritalin, Concerta, etc.) |
| 1205 | stimulant | Lisdexamfetamine (Vyvanse), its salts, isomers, and salts of its isomers |
| 2125 | depressant | Amobarbital |
| 2550 | depressant | Glutethimide |
| 2270 | depressant | Pentobarbital |
| 7471 | depressant | Phencyclidine |
| 2315 | depressant | Secobarbital |
| 7379 | hallucinogen | Nabilone |
| 8501 | precursor | Phenylacetone |
| 7460 | precursor | 1-phenylcyclohexylamine |
| 8603 | precursor | 1-piperidinocyclohexanecarbonitrile (PCC) |
| 8333 | precursor | 4-anilino-N-phenethyl-4-piperidine (ANPP) |
References[edit]
- ^ ab21 CFR1308.12 (CSA Sched II) with changes through 77 FR64032 (Oct 18, 2012). Retrieved September 6, 2013.
- ^21 U.S.C.§ 812(b)(4) retrieved October 7, 2007
Saahil AroraDepartment of Pharmaceutics, ISF College of Pharmacy, Moga (Punjab), India 2(M) ABSTRACTPoor aqueous solubility impedes a drug's bioavailability and challenges its pharmaceutical development. Pharmaceutical development of drugs with poor water solubility requires the establishment of a suitable formulation layout among various techniques. Various approaches have been investigated extensively to improve the aqueous solubility and poor dissolution rate of BCS class II and IV drugs. In this literature review, novel formulation options, particularly for class II drugs designed for applications such as micronization, self-emulsification, cyclodextrin complexation, co-crystallisation, super critical fluid technology, solubilisation by change in pH, salt formation, co-solvents, melt granulation, and solid dispersion, liposomal/niosomal formulations, are discussed in detail to introduce biopharmaceutical challenges and recent approaches to facilitate more efficient drug formulation and development.